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CVS Pharmacology

CVS Pharmacology

by Md. Anamul Haque -
Number of replies: 11

What is the pharmacotherapy for Congestive heart failure?

Write in short.

In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Urmi Datta gupta -
Classes of drugs used to treat systolic congestive heart failure today include digoxin, diuretics, ACE inhibitors, angiotensin receptor antagonists , beta blockers, aldosterone antagonists, a drug combination that increases.Currently used therapeutics in the treatment of chronic congestive heart failure. Symptomatic treatment is usually perfor med along the following lines: rest, sodium and fluid restriction to unload the decompensating heart, loop diuretics, angiotensin-converting enzyme inhibitors or other vasodilators; inotropic agents to improve the heart's mechanical performance; attempts to counteract the neuro-endocrine compensatory mechanisms, that is the activated sympathetic nervous and renin-angiotensin-aldosterone systems, as well as the rise in vasopressine levels.
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Sadia Afsana Mim -
Congestive heart failure (CHF) continues to be a lethal end stage of cardiovascular diseases caused by hypertension, coronary heart disease, valve deformity, diabetes and cardiomyopathy. Current therapy for CHF can maintain function, improve quality of life, and prolong survival. Diuretics, angiotensin-converting enzyme inhibitors (ACE), and digoxin remain in standards of therapy. Diuretics remains an important component of the symptomatic management of patients with CHF, but severe patients may require additional agents. One option frequently used in patients who exhibit resistance to loop diuretics is infusion of low-dose dopamine. Combination diuretics may effectively increase urine output, with the addition of thiazide or spironolactone. Documentation of the clinical benefit of ACE inhibitors represents the most important advance in therapeutics for CHF in the last decade. ACE inhibitors improves left ventricular function, and survival.
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Most. Nazmin Aktar -

Congestive heart failure (CHF) is a chronic progressive condition that affects the pumping power of your heart muscle. While often referred to simply as heart failure. Congestive heart failure may be primarily systolic or diastolic.The pharmacotherapy of congestive heart failure must attack both components of the condition: pulmonary edema and inadequate cardiac performance.


 1. Digoxin

 2. ACE Inhibitors/ARBs

 3. Beta Blocker

 4. Aldosterone Antagonists

 5. HCN4 Inhibitor

 6. Neprilysin Inhibitor/ARB

 7. Calcium chennel bolcker  8. Loop diuretic + nitroglycerin + oxygen (same as systolic congestive heart failure)


Above mentioned pharmacotherapy is given if someone affected by the CHF( Congestive Heart Failure).

In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Md Moin Uddin -

The pharmacotherapy of congestive heart failure must attack both components of the condition: pulmonary edema and inadequate cardiac performance. 

This pharmacotherapy is given if someone affected by the CHF( Congestive Heart Failure).

 1. Digoxin

 2. ACE Inhibitors/ARBs

 3. Beta Blocker

 4. Aldosterone Antagonists

 5. HCN4 Inhibitor

 6. Neprilysin Inhibitor/ARB

 7. Calcium chennel bolcker  8. Loop diuretic + nitroglycerin + oxygen (same as systolic congestive heart failure)

In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Salman Farshe -
Congestive heart failure (CHF) is a chronic progressive condition that affects the pumping power of your heart muscle. While often referred to simply as heart failure. Congestive heart failure may be primarily systolic or diastolic.The pharmacotherapy of congestive heart failure must attack both components of the condition pulmonary edema and inadequate cardiac performance.
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Ishrat Jahan Bristy -
Congestive heart failure (CHF) is a chronic progressive condition that affects the pumping power of your heart muscle. While often referred to simply as heart failure. Congestive heart failure may be primarily systolic or diastolic.The pharmacotherapy of congestive heart failure must attack both components of the condition pulmonary edema and inadequate cardiac performance.

Classes of drugs used to treat systolic congestive heart failure today include digoxin, diuretics, ACE (angiotensin converting enzyme) inhibitors, angiotensin receptor antagonists (ARBs), beta blockers, aldosterone antagonists, a drug combination that increases NO, an ARB/neprilysin inhibitor combination, and an HCN4 blocker.
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Anika Tahsin -
Heart failure, sometimes known as congestive heart failure, occurs when your heart muscle doesn't pump blood as well as it should. While often referred to simply as heart failure. Congestive heart failure may be primarily systolic or diastolic.The pharmacotherapy of congestive heart failure must attack both components of the condition pulmonary edema and inadequate cardiac performance.

Classes of drugs used to treat systolic congestive heart failure today include digoxin, diuretics, ACE (angiotensin converting enzyme) inhibitors, angiotensin receptor antagonists (ARBs), beta blockers, aldosterone antagonists, a drug combination that increases NO, an ARB/neprilysin inhibitor combination, and an HCN4 blocker.
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Smarak Islam -
Therapeutic Recommendations for Systolic Congestive Heart Failure:
  • Acute Therapy: Loop diuretic + nitroglycerin + oxygen.
  • Chronic Therapy:
  1.  Diuretic: thiazide diuretic, loop diuretic, or both, depending on severity of congestion
  2.  Anti-Remodeling Therapy: ACE inhibitor (or ARB or Entresto) + β blocker. Add aldosterone antagonist, if serum K+ can be monitored on a regular basis. Consider adding ivabradine, if β blocker ± digoxin does not reduce heart rate to 70-75/min.
  3.  Digoxin: add if LVEF remains <30% or declines despite optimal remodeling therapy + diuretic.
  4.  Hydralazine/isosorbide dinitrate: consider for African-Americans in addition to or as a substitute for ACE inhibitor/ARB.
Therapeutic Recommendations for Diastolic Congestive Heart Failure:
  • Acute Therapy: Loop diuretic + nitroglycerin + oxygen (same as systolic congestive heart failure)
  • Chronic Therapy:
  1.  Diuretic: thiazide diuretic, loop diuretic, or both, depending on severity of congestion
  2.  Symptomatic therapy: ACE inhibitor (or ARB) + β blocker, verapamil, or diltiazem
In reply to Md. Anamul Haque

Re: CVS Pharmacology

by suman Majumdar -

Heart failure, sometimes known as congestive heart failure, occurs when heart muscle doesn't pump blood on the heart. Certain conditions, such as narrowed arteries in heart (coronary artery disease) or high blood pressure, gradually leave heart too weak or stiff to fill and pump efficiently.

Not all conditions that lead to heart failure can be reversed, 

 conditions that cause heart failure, such as coronary artery disease, high blood pressure, diabetes or obesity.

Shortness of breath (dyspnea)

Fatigue and weakness

Rapid or irregular heartbeat

Reduced ability to exercise

Persistent cough or wheezing with white or pink blood-tinged phlegm

Increased need to urinate at night

Swelling of your abdomen.

Acute Therapyl

Loop diuretic + nitroglycerin + oxygen

 Chronic Therapy

 1.  Diuretic: thiazide diuretic, loop diuretic, or both, depending on severity of congestion

2.  Anti-Remodeling Therapy: ACE inhibitor (or ARB or Entresto) + β blocker.  Add aldosterone antagonist, if serum K+ can be monitored on a regular basis.  Consider adding ivabradine, if β blocker ± digoxin does not reduce heart rate to 70-75/min.

3. Digoxin: add if LVEF remains <30% or declines despite optimal remodeling therapy +          diuretic.

4.  Hydralazine/isosorbide


In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Shohana Rahaman Snigdha -

Congestive heart failure (CHF) is a condition in which the heart can no longer sufficiently supply the body with the blood needed to maintain homeostasis. This condition can result from other cardiovascular complications such as infarctions, valve defects, lung disease, and hypertension. Left-sided heart failure occurs more frequently than right-sided, creating symptoms like shortness of breath and irregular heart rhythm which can induce compensatory mechanisms of the body. 

Classes of drugs used to treat systolic congestive heart failure today include digoxin, diuretics, ACE inhibitors, angiotensin receptor antagonists , beta blockers, aldosterone antagonists, a drug combination that increases.Currently used therapeutics in the treatment of chronic congestive heart failure. Symptomatic treatment is usually perfor med along the following lines: rest, sodium and fluid restriction to unload the decompensating heart, loop diuretics, angiotensin-converting enzyme inhibitors or other vasodilators; inotropic agents to improve the heart's mechanical performance; attempts to counteract the neuro-endocrine compensatory mechanisms, that is the activated sympathetic nervous and renin-angiotensin-aldosterone systems, as well as the rise in vasopressine levels.

In reply to Md. Anamul Haque

Re: CVS Pharmacology

by Rezwana Karim -
One of the most common causes of death and disability in the world is congestive heart failure. At least in some cases, systolic and diastolic congestive heart failure are two stages of the same disease, with diastolic congestive heart failure being the early stage (myocyte hypertrophy) and systolic congestive heart failure being the late stage (myocyte apoptosis).

Systolic congestive heart failure: Systolic congestive heart failure is characterized by massive, dilated ventricles that are deteriorated and contract weakly. It is most usually linked with ischemic heart disease.
Digoxin, diuretics, ACE inhibitors, angiotensin receptor antagonists (ARBs), beta blockers, aldosterone antagonists, a medication combination that raises NO, an ARB/neprilysin inhibitor combo, and an HCN4 blocker are some of the medications used to treat systolic congestive heart failure today.

Diastolic congestive heart failure: Heart failure with normal ejection fraction is a term that is increasingly being used to describe diastolic congestive heart failure. Diastolic congestive heart failure is characterized by hypertrophied, insufficiently compliant ventricular walls and is most typically associated with long-term hypertension.
Because the contraction strength is normal or supranormal, inotropic medications are not employed to treat diastolic congestive heart failure. Instead, a calcium channel blocker or blocker is needed to relax heart muscle and prolong diastolic filling, increasing the compliance of the ventricular wall and allowing the ventricle to fill with more blood. ACE inhibitors/ARBs are another common treatment options, though it's unclear whether they're better than other vasodilators.