Introductory discussion

Population Genetics

Population Genetics

by Md. Al Rahat Khan -
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Population Genetics

 

 

 

Population genetics is concerned with genetic differences within and across populations, and the dynamics of how populations evolve as a result of the propagation of genetic mutations occurring within the germlines of individuals. This article provides a mathematical approach to the most commonly used population genetics models, including Wright-Fisher and related models, and also the less-commonly encountered Bienaymé-Galton-Watson branching model. Topics include fixation times, mutations and their relationship to substitution rates in neutral evolution, selection, multiple alleles, the diffusion limit via the forward Kolmogorov equation, multiple alleles, coalescent theory, and parameter estimation