Lecture No.

Topics Name/

Chapter Name

Sub-topics /

Lecture Topics

L-1

Combinatorial

Chemistry

Introduction & general discussion on combinatorial chemistry.

L-2

Definition, design & general concept of Combinatorial synthesis, its role in medicinal chemistry.

L-3

Solid Phase technique- advantages & requirements. Chemistry of linkers & protecting group. Merrifield’s peptide synthesis.

L-4

Parallel synthesis. Mixed synthesis- mix & split method, isolating active compound.

L-5

Structure determination of active compound. Encoding combinatorial libraries. Solution phase Combinatorial synthesis- parallel techniques.

L-6

Mixed solution phase synthesis. Chemistry & use of soluble supports. Limitation of combinatorial synthesis. Designing of combinatorial synthesis.