Syllabus
Syllabus
BPH 411 Medicinal Chemistry -III 3 credits
(Pre-requisite-Medicinal Chemistry-I & II)
1. Combinatorial chemistry:
a) Combinatorial synthesis: Introduction to drug discovery process, b) library synthesis on resin beads- solid phase chemistry, resin beads, speeding up of peptide synthesis, mix and split library synthesis, c) solution phase, indexed combinatorial libraries, template-based libraries, liquid phase combinatorial synthesis, d) encoded combinatorial synthesis- encoded requirements, examples of tagged libraries, e) solid phase library, chemistry of linkers, carboxylic acid linkers, carboxamide linkers, alcohol linkers, amine linkers, traceless linkers, light-cleavable linkers, selected solid phase chemistry, f) analysis of products with different analytical techniques g) combinatorial chemistry: applications and impact on drug discovery.
2. Knowledge of the chemistry (including synthesis), structure activity relationships and physicochemical properties of the following groups of medicinal substances:
a. Proton pump inhibitors
b. Tranquilizing agents
c. Anti-asthmatic agents
d. Antitubercular agents
e. Anti-diarrheal agents
f. Anti-malarial agents
g. Anti-cancer agents
h. Membrane acting drugs: Drugs acting on Ca++, K+, Na+ channels
i. Antithyroid drugs
h. Oral contraceptives and steroidal hormones, hormone replacement therapy
3. Natural products and secondary metabolites as drugs:
a) Vitamins: The clinical aspects of the vitamins and their effects on free radicals, synthesis of the vitamins such as vit-B1, vit-C, nicotinamide, pyridoxine, mechanism of action of vitamins.
b) Alkaloids: Alkaloids as pharmaceutical raw materials, opium and analogues of opium, synthesis of papaverine and ephedrine, clinical comparison of ephedrine and epinephrine.
c) Glycosides: Chemical and clinical aspects of digoxin and other digitalis glycosides.