Course Outline
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COURSE DETAILS |
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Course title |
Medicinal Chemistry –III
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Entry qualifications |
Must be completed Medicinal Chemistry –I & II
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Maximum number in class |
30
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Average class contact hours per week |
3 Hours |
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Examining body |
Mashiur Rahman |
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Academic level |
B. Pharm |
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Duration of course |
6 Months |
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Teacher/Course Leader responsible for the course |
Mashiur Rahman
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Brief outline of the course content and its delivery:
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Lecture No. |
Topics Name/ Chapter Name |
Sub-topics / Lecture Topics |
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L-1 |
Combinatorial Chemistry |
Introduction & general discussion on combinatorial chemistry. |
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L-2 |
Definition, design & general concept of Combinatorial synthesis, its role in medicinal chemistry. |
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L-3 |
Solid Phase technique- advantages & requirements. Chemistry of linkers & protecting group. Merrifield’s peptide synthesis. |
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L-4 |
Parallel synthesis. Mixed synthesis- mix & split method, isolating active compound. |
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L-5 |
Structure determination of active compound. Encoding combinatorial libraries. Solution phase Combinatorial synthesis- parallel techniques. |
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L-6 |
Mixed solution phase synthesis. Chemistry & use of soluble supports. Limitation of combinatorial synthesis. Designing of combinatorial synthesis. |
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QUIZ TEST-1, Marks-10 |
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L-7 to L-8 |
Chemical & physicochemical property & SAR of some medicinal groups |
Proton pump inhibitors- structure of proton pump, mechanism of acid secretion, synthesis of a PPI. Mechanism, design & SAR of proton pump inhibitors |
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L-9 |
Tranquilizing agent-types & mechanism. |
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L-10 to L-11 |
Anti-diarrheal agents: Chemistry, mechanism & SAR. |
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L-12 |
Anti-tubercular agents: therapeutic classification, mechanism & SAR. |
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QUIZ TEST-2, Marks-10 |
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Assignment (Marks 5) |
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Midterm Examination (25 marks) |
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L-13 |
Chemical & physicochemical property & SAR of some medicinal groups |
Anti-asthmatic drug: Pathogenesis & treatment of asthma. Therapeutic classification of anti asthmatic drug, their mechanism & SAR. |
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L-14 |
Anti-malarial agents: Causes of malaria, stages of development of malaria & target for drug action. Malarial vaccines. Drug therapy |
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L-15 |
Mechanism, SAR & metabolism of various types of anti-malarial drugs. Polycyclic Anti-malarial Drugs, New Anti-malarial Drugs |
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Presentation (5 marks) |
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L-16 |
Chemical & physicochemical property & SAR of some medicinal groups |
Anti-cancer agents: tumor cell properties, biological properties of anticancer drugs. Types of anticancer drugs. |
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L-17 |
Alkylating agents- Chemistry & mechanism. Alkylation of guanine of DNA. |
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L-18 |
Antimetabolites- Chemistry, synthesis & mechanism. |
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L-19 |
Anticancer antibiotics & Other anticancer agents. |
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QUIZ TEST-3, Marks-10 |
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L-20 |
Chemical & physicochemical property & SAR of some medicinal groups |
Membrane acting drugs: Drugs acting on Ca++, K+, Na+ channels. |
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L-21 |
Antithyroid drugs: Disease involved in thyroid gland, Types of therapeutic agents |
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L-22 |
Thyroid hormone analogues- SAR & conformational properties. |
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L-23 |
Hormonal drugs: Clinical applications of Oral contraceptives and steroidal hormones, their aspects of biosynthesis. Hormone replacement therapy. |
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L-24 |
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L-25 |
Hormonal drugs: Drug metabolism & SAR. |
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L-26 |
Natural products and secondary metabolites as drugs |
Vitamins: The clinical aspects of the vitamins and their effects on free radicals, synthesis of the vitamins |
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L-27 |
Vitamins: synthesis & mechanism of action of vitamins. |
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L-28 |
Alkaloids: Alkaloids as pharmaceutical raw materials, opium and analogues of opium. |
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L-29 |
Alkaloids: synthesis of papaverine and ephedrine, clinical comparison of ephedrine and epinephrine. |
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L-30 |
Glycosides: Chemical and clinical aspects of digoxin and other digitalis glycosides, Steroids & Antisteroids |
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Semester Final Examination (50 marks) |
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