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Lecture No.
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Topics Name/
Chapter Name
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Sub-topics /
Lecture Topics
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L-1
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Combinatorial
Chemistry
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Introduction & general
discussion on combinatorial chemistry.
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L-2
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Definition, design & general
concept of Combinatorial synthesis, its role in medicinal chemistry.
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L-3
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Solid Phase technique- advantages
& requirements. Chemistry of linkers & protecting group. Merrifield’s
peptide synthesis.
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L-4
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Parallel synthesis. Mixed synthesis-
mix & split method, isolating active compound.
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L-5
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Structure determination of active
compound. Encoding combinatorial libraries. Solution phase Combinatorial
synthesis- parallel techniques.
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L-6
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Mixed solution phase synthesis.
Chemistry & use of soluble supports. Limitation of combinatorial
synthesis. Designing of combinatorial synthesis.
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QUIZ TEST-1, Marks-10
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L-7
to L-8
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Chemical & physicochemical property & SAR of
some medicinal groups
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Proton pump inhibitors- structure of
proton pump, mechanism of acid secretion, synthesis of a PPI. Mechanism, design
& SAR of proton pump inhibitors
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L-9
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Tranquilizing agent-types & mechanism.
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L-10
to L-11
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Anti-diarrheal agents: Chemistry,
mechanism & SAR.
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L-12
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Anti-tubercular agents: therapeutic
classification, mechanism & SAR.
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QUIZ TEST-2, Marks-10
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Midterm Examination (25 marks)
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L-13
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Chemical & physicochemical property & SAR of
some medicinal groups
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Anti-asthmatic drug: Pathogenesis
& treatment of asthma. Therapeutic classification of anti asthmatic drug,
their mechanism & SAR.
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L-14
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Anti-malarial agents: Causes of
malaria, stages of development of malaria & target for drug action.
Malarial vaccines. Drug therapy
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L-15
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Mechanism, SAR & metabolism of
various types of anti-malarial drugs. Polycyclic Anti-malarial Drugs, New
Anti-malarial Drugs
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Presentation (5 marks)
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L-16
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Chemical & physicochemical property & SAR of
some medicinal groups
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Anti-cancer agents: tumor cell properties,
biological properties of anticancer drugs. Types of anticancer drugs.
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L-17
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Alkylating agents- Chemistry &
mechanism. Alkylation of guanine of DNA.
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L-18
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Antimetabolites-
Chemistry, synthesis & mechanism.
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L-19
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Anticancer
antibiotics & Other anticancer agents.
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QUIZ TEST-3, Marks-10
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L-20
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Chemical & physicochemical property & SAR of
some medicinal groups
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Membrane acting drugs: Drugs acting
on Ca++, K+, Na+ channels.
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L-21
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Antithyroid drugs: Disease involved
in thyroid gland, Types of therapeutic agents
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L-22
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Thyroid
hormone analogues- SAR & conformational properties.
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L-23
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Hormonal
drugs: Clinical applications of Oral contraceptives and steroidal hormones, their
aspects of biosynthesis. Hormone replacement therapy.
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L-24
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L-25
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Hormonal
drugs: Drug metabolism & SAR.
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L-26
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Natural products and secondary metabolites as drugs
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Vitamins: The clinical aspects of the vitamins and
their effects on free radicals, synthesis of the vitamins
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L-27
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Vitamins: synthesis &
mechanism of action of vitamins.
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L-28
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Alkaloids: Alkaloids as pharmaceutical raw materials, opium and analogues of
opium.
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L-29
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Alkaloids: synthesis of papaverine
and ephedrine, clinical comparison
of ephedrine and epinephrine.
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L-30
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Glycosides:
Chemical and
clinical aspects of digoxin and other digitalis glycosides, Steroids &
Antisteroids
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Semester Final Examination (50 marks)
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